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Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds Raibaut, L.; Drobecq, H.; Melnyk, O. Org. Lett. 2015, 17, 3636–3639. DOI : 10.1021/acs.orglett.5b01817


Synthesis of unprotected linear or cyclic O-acyl isopeptides in water using bis(2-sulfanylethyl)amido peptide ligation Desmet, R. ; Pauzuolis, M.; Boll, E.; Drobecq, H.; Raibaut, L.; Melnyk, O. Org. Lett. 2015, 17, 3354-3357. DOI: 10.1021/acs.orglett.5b01614


One-pot chemical synthesis of small ubiquitin-like modifier (SUMO) protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates Boll, E.; Drobecq, H.; Ollivier, N.; Blanpain, A.; Raibaut, L.; Desmet, R.; Vicogne, J. & Melnyk, O. Nat. Protocols 2015, 10, 269-292.

DOI: 10.1038/nprot.2015.013


Solid phase protein synthesis Raibaut, L., El Madhi, O., Melnyk, O. Topics Curr. Chem. 2015, 363, 103-154. DOI: 10.1007/128_2014_609


Access to large cyclic peptides by a one-pot two peptide segments ligation/cyclization process Boll, E. ; Ebran, J.-P.; Drobecq, H.; El-Mahdi, O.; Raibaut, L.; Ollivier, N.; Melnyk, O. Org. Lett. 2015, 17, 130-133. DOI: 10.1021/ol503359w


Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist Simonneau, C.; Leclercq, B.; Mougel, A.; Adriaenssens, E.; Paquet, C.; Raibaut, L.; Ollivier, N.; Drobecq, H.; Marcoux, J.; Cianférani, S.; Tulasne, D.; De Jonge, H.; Melnyk, O.; Vicogne, J. Chem. Sci., 2015,6, 2110-2121.

DOI: 10.1039/C4SC03856H